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CVM Faculty, Staff and Student Accolades

The MU College of Veterinary Medicine salutes our faculty, staff and students for their many achievements. We take pride in sharing their accomplishments.

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Mizzou Researchers Obtain Funding for COVID Related Animal Modeling Projects

A team of researchers at the MU College of Veterinary Medicine Department of Veterinary Pathobiology recently obtained two grants from the National Institutes of Health that focus on finding more effective animal models for COVID-19 research. The team includes members of several of the MU’s unique resources including Elizabeth Bryda, PhD, director of the MU Animal Modeling Core and the NIH-funded Rat Resource and Research Center, Craig Franklin, DVM, PhD, DACLAM and Jim Amos-Landgraf, PhD, co-directors of the NIH-funded Mutant Mouse Resource and Research Center, Aaron Ericsson, DVM, PhD, director of the MU Metagenomics Center, Daniel Davis, PhD, assistant director of the MU Animal Modeling Core, and Deborah Anderson, PhD, and Paul Anderson, PhD, of the Laboratory for Infectious Disease Research.

Franklin and Amos-Landgraf’s project is titled “Optimization of Murine Models of COVID-19 through Gut Microbiota Manipulation.” The goal of this project is to refine the pre-eminent mouse model for COVID research, the K18-hACE2 transgenic mouse so that it is optimally translatable to the human condition. Unlike humans, research mice are raised in pristine environmental conditions and this results in the mouse’s immune system being more similar to a neonatal human than an adult. This is likely because mice are rarely exposed to viral and bacterial diseases that most humans experience as they grow up (e.g. the common cold). To promote the development of an adult immune system in mice, one can expose mice to similar disease-causing agents as well as modify the gut microbiota, the complex communities of thousands of bacteria that inhabit the intestinal tract. Briefly, this project is asking if different microbial communities and previous disease exposures can change the severity of COVID-19 infection in this mouse model. “We’re interested in knowing if it’s the best model it can be,” said Franklin. “Can we refine it to the point where what we see in a mouse is identical to what we see in people?”

The project Bryda is leading, titled, “Generation of Novel Rat Models for the Study of SARS-CoV-2 and COVID-19,” focuses on rats, which may be able to recapitulate human disease better than mice. She is using state-of-the art genetic engineering technology, including the use of CRISPR-Cas9, to create models that have the human ACE2 receptor, the receptor to which SARS-CoV-2 binds. Several new rat strains will be developed that will allow questions about the impact of sex, age, genetic background and levels of expression of the viral receptor on disease symptoms and severity to be explored. “We’re going to use a different strategy, make these genetically engineered rats in a different way than the existing mouse models and hope that they will be a more improved animal model for studying COVID-19,” said Bryda.

Both models rely on being able to infect mice and rats with SARS-CoV-2, the virus that causes COVID-19.  To do so requires highly specialized facilities such as the Laboratory of Infectious Disease Research, (LIDR), one of 12 regional biocontainment laboratories funded in part by NIH’s National Institute of Allergy and Infectious Diseases (NIAID) to perform biosafety level three research on infectious agents such as nCoV2-SARS.

The mouse model grant comes in the form of $378,922 and the rat model grant is $203,950. According to the group, they were approached by the NIH to submit applications because of the unique resources here on the MU campus and these played a critical role in ultimately obtaining funding. Franklin summarized this effort saying, “Very few places in the country have the expertise we have here.”

By Nick Childress

Booth and Rector Awarded $1.5 million NIH Grant

The National Institutes of Health has awarded Frank Booth, PhD, professor in the College of Veterinary Medicine Department of Biomedical Sciences, and R. Scott Rector, PhD, associate professor in the MU School of Medicine Department of Nutrition and Exercise Physiology a grant for their research focusing on the effects of the liver on brain function. The title of the study is “Molecular Transducers of Physical Activity: Liver Adaptations Drive Brain Benefits.” The NIH award is more than $1.5 million and will fund the research for three years.

The goal of this study is to see how exercise affects the liver, and therefore affects brain function of rats. The study involves having the animals run on treadmills and then conducting a series of harmless behavioral tests to determine the extent that liver health is improving the brain function. Booth says the research is important for understanding how we may be able to combat and prevent neurodegenerative diseases in humans through exercise. “If there are no therapies to cure these neurodegenerative diseases, then the alternative is to keep people from getting them,” Booth says. “We’re going to try to figure out which genes are affected and then either people will be encouraged to exercise, or people can then develop therapies to prevent neurodegenerative diseases.”

Nichols and Lever Receive $1.9 million NIH Grant

The National Institutes of Health has awarded a $1.9 million MPI R01 grant to Nicole Nichols, PhD, assistant professor in the Department of Biomedical Sciences at the University of Missouri College of Veterinary Medicine and Dalton Cardiovascular Research Center investigator, and Teresa Lever, PhD, associate professor of otolaryngology at the MU School of Medicine.

The goal of their research is to understand how breathing and swallowing deteriorates in rats whose motor neurons responsible for upper airway function are selectively eliminated, and to determine if a non-invasive, individualized exercise program designed to strengthen tongue function can preserve swallowing and breathing function and coordination. This study will allow them to determine the underlying mechanism of exercise induced preservation and plasticity of upper airway function in the surviving motor neurons responsible for swallowing and breathing function and coordination. Ultimately, this project could lead to future translational studies involving people.

Kerl Receives VECCS Ira Zaslow Distinguished Service Award

Congratulations to Marie Kerl, DVM, MPH, DACVIM-Small Animal Internal Medicine, DACVECC, an adjunct teaching professor in pathobiology at the University of Missouri College of Veterinary Medicine, on receiving the Veterinary Emergency and Critical Care Society’s Ira Zaslow Distinguished Service Award.

Marie KerlThis award is the highest honor the VECCS presents, and is given annually to an individual who has demonstrated extraordinary commitment and exceptional contribution to the specialty of emergency and critical care, as well as to the VECCS. The award is named after Ira M. Zaslow, one of the founding fathers of the VECCS and the ACVECC.

Kerl has served in many positions for the VECCS, including member-at-large on the board of directors, president-elect, president and past-president. She also served on the American College of Veterinary Emergency and Critical Care board of regents as vice-president, where she also led the ACVECC Scientific Program Committee. Kerl has been a member on the editorial board of the Journal of Emergency and Critical Care since 2004, and currently serves as an assistant editor. She has also been a member of the National Veterinary Response Team since 2007 and has been the regional medical director for Veterinary Centers of America since 2017 and regional operations director since 2020.

A press release from the VECCS stated, “Dr. Kerl has dedicated invaluable hours as a member of the ACVECC Examination Committee, further demonstrating her passion for mentoring, training and certifying the next generation of veterinary leaders and colleagues.”

Mohan Lab Receives NIH/NIAID Travel Award

Congratulations to Rajiv Mohan, PhD, FARVO, and his lab team on receiving the Travel Award from the National Institutes of Health, National Institute of Allergy and Infectious Diseases. Sabeeh Kamil, MBBS, a research fellow in the lab, received the prestigious award for presenting his research findings at the trans-agency scientific meeting titled, “Developing Medical Countermeasures to Treat Acute and Chronic Effects of Ocular Chemical Toxicity” held Feb. 25-26, in Rockville, Maryland.

From left to right Rajiv Mohan PhD (professor), Ratnakar Tripathi PhD (research assistant professor), Praveen Balne PhD (postdoctoral fellow), Lynn. Martin DVM (PhD graduate student), Suneel Gupta PhD (research assistant professor), Nishant Sinha BS (PhD graduate student), and Sabeeh Kamil MBBS (research fellow).
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Giving to the MU College of Veterinary Medicine

Giving to the College of Veterinary MedicineThe MU College of Veterinary Medicine is Missouri’s only institution that confers the Doctor of Veterinary Medicine degree. Thank you for exploring how you can partner with us to make a positive difference in the lives of animals and people.

Whether your interest in supporting our mission to teach, heal, discover and serve is inspired by care your pet received, the desire to help less fortunate animals and their families, an interest in helping the next generation of veterinarians pursue their dreams, or the wish to be a part of a medical breakthrough, we are grateful for your thoughtful consideration. We have many programs that will benefit from additional financial support.

Learn more about how your gift can help the College of Veterinary Medicine.

BIOMED Online

In addition to the four-year professional curriculum leading to the Doctor of Veterinary Medicine (DVM) degree, the college offers a variety of online (BIOMED) courses. Courses serve as electives for other degree programs, a component to the online health science and bachelor of general studies degrees, as partial requirements in the MU Pre-veterinary Medicine Scholars Program, and to earn either a thesis or non-thesis master’s degree. BIOMED courses are also recommended electives in meeting the requirements to apply for a DVM program.

University of Missouri Veterinary Online Programs/BIOMED Online

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