Elizabeth Coco Bryda
Associate Professor
  • M.S. Microbiology – Rutgers University/University of Medicine & Dentistry of NJ
  • Ph.D, Rutgers University/University of Medicine & Dentistry of NJ
  • Postdoctoral Training: Molecular Genetics - Wadsworth Center, Albany, NY

    • brydae@missouri.edu

    Research emphasis: Our laboratory takes a comparative medicine approach to studying human disorders by using a variety of animal models of disease. The current emphasis in the lab is on the study of polycystic kidney disease and hereditary deafness. Using both rodent and zebrafish models, we are interested in characterizing disease-causing genes and their protein products in order to elucidate the molecular pathways in which these genes/proteins participate. This knowledge will allow a better understanding of both normal and abnormal development in the kidney or the inner ear and may ultimately lead to the development of targeted therapeutics. Another focus of the laboratory is to develop tools and diagnostics in the field of laboratory animal medicine. We have developed panels of multiplexed microsatellite markers for improved genetic characterization and monitoring of laboratory animals, including mouse, rat, and pig. We are currently developing efficient and cost-effective methods to validate and authenticate cell lines from any species, including human cell lines.

    Teaching: Laboratory Animal Medicine, Human Genetics

    Selected publications:

    Bouvrette, D.J., Price, S.J., Bryda, E.C. The K Homology Domains of the Mouse Polycystic Kidney Disease-related Protein Bicaudal-C (Bicc1) Mediate RNA Binding In Vitro. Nephron: Experimental Nephrology (2008).

    Bryda, E.C. and Riley, L.K. Multiplex Microsatellite Markers Panels for Genetic Monitoring of Common Rat Strains. Comparative Medicine (2008)

    Bauer, B.A., Boedges, S., Cook, C.R., Bryda, E.C, Franklin, C. L. Breeding Colony Refinement Through Phenotypic and Genotypic Characterization of the SPRD-Pkdr1/Rrrc Rat Model of Polycystic Kidney Disease. Comparative Medicine 57:193-199 (2007).

    Bryda, E.C., Pearson, M., Agca, Y., Bauer, B.A. Method for Detection and Identification of Multiple Chromosomal Integration Sites in Transgenic Animals Created with Lentivirus. Biotechniques 41:715-719 (2006).

    Cogswell, C., Price, S. J., Hou, X., Guay-Woodford, L.M., Flaherty, L., and Bryda, E. C. Positional cloning of the jcpk/bpk locus of the mouse. Mammalian Genome 14:242-249 (2003).

    Price, S.J., Chittenden, L., Flaherty, L., O’Dell, B., Guay-Woodford, L.M., Stubbs, L. and Bryda, E.C. Characterization of the Region Containing the jcpk PKD Gene on Mouse Chromosome 10. Cytogenetics and Genome Research 98:61-66 (2002).

    Bryda, E.C., Kim, H.J., Legare, M.E., Frankel, W. and Noben-Trauth, K. High resolution genetic and physical mapping of modifier-of-deafwaddler (mdfw) and waltzer (v). Genomics 73: 338-342 (2001).

    Di Palma, F., Holme, R.H., Bryda, E.C., Belyantseva, I.A., Pellegrino, R., Kachar, B., Steel, K.P. and Noben-Trauth, K. Mutations in Cdh23, encoding a new type of cadherin, cause stereocilia disorganization in waltzer, the mouse model for Usher syndrome type 1D. Nature Genetics 27: 103-107 (2001).

    Bolz, H., von Brederlow, B., Ramirez, A., Bryda, E.C., Kutsche, K., Nothwang, H-G, Seeliger, M., Cabrera, M. d.C-S., Vila, M.C., Molina, O.P., Gal, A. and Kubisch, C. Mutation of CDH23, encoding a new member of the cadherin gene family, causes Usher syndrome type 1D. Nature Genetics 27:108-112 (2001).