Guoquan Zhang
Assistant Professor
  • DVM, Veterinary Medicine, Inner Mongolia Agricultural University, Huhehot, China
  • Ph.D., Microbiology & Immunology, University of Gifu, Gifu, Japan
  • M.S., Virology, Chinese Academy of Agricultural Sciences, Beijing, China

    • zhangguo@missouri.edu

    Research emphasis: Dr. Zhang’s research focuses on the elucidation of mechanisms of protective immunity against Coxiella burnetii infection. C. burnetii is an obligate gram-negative intracellular bacterium that causes acute Q fever and chronic infections in humans. The highly infectious nature of C. burnetii and its hardiness in adverse environmental conditions make the organism attractive for misuse in bioterrorism and biological warfare. Our research program involves understanding the host immune response and protective vaccination to C. burnetii infection in animal models. We are particularly interested in understanding the role of dendritic cells in presenting C. burnetii antigen and regulating T cell-mediated immunity against C. burnetii infection.

    Graduate positions available, click here for details.

    Selected publications:

    Zhang GQ, Kiss K, Seshadri R, Hendrix L, Samuel J. Identification and cloning of immunodominant antigens of Coxiella burnetii. Infect Immun. 2004:72;844-852.

    Hotta A, Zhang GQ, Andoh M, Yamaguchi T, Fukushi H and Hirai K. Use of monoclonal antibodies for analyses of Coxiella burnetii major antigens. J Vet Med Sci. 2004:66(10);1289-1291.

    Brennan RE, Russell KE, Zhang GQ, Samuel J. Both iNOS and NADPH oxidase contribute to controlling virulent phase I Coxiella burnetii infections. Infect Immun. 2004:72;6666-6675.

    Zhang GQ, Samuel JE. Vaccines against Coxiella infection. Expert Rev Vaccines. 2004 Oct:3(5);577-584.

    Zhang GQ, Ho T, Russell KE, Hendrix LR, Yamaguchi T, Fukushi H, Hirai K, Samuel J. Identification and characterization of an acute disease-associated isolates specific immunodominant 28 kDa outer membrane protein of Coxiella burnetii. Infect Immun. 2005:73;1561-1567.

    Russell-Lodrigue KE, Zhang GQ, McMurray DN, Samuel J. Clinical and pathologic changes in a Guinea pig aerosol-challenge model of acute Q fever. Infect Immun. 2006:74;6085-6091.

    Masako A, Zhang GQ, Russell-Lodrigue KE, Shive HR, Weeks BR, Samuel JE. T cells are essential for bacterial clearance and IFN? TNF?, and B cells are crucial for disease development in Coxiella burnetii infection in mice. Infect Immun. 2007:75;3245-3255.

    Zhang GQ, Russell-Lodrigue KE, Andoh M, Zhang Y, Hendrix LR, Samuel JE. Mechanisms of vaccine-induced protective immunity against Coxiella burnetii infection in BALB/c mice. J Immunol. 2007:179;8372-8380.