DNA Tests Performed by the University of Missouri Canine Genetics Laboratory

The University of Missouri Canine Genetics Laboratory performs testing to identify selected disease-causing mutations in dogs.  Some of our testing is offered in coordination with the Orthopedic Foundation for Animals (OFA).  The tests offered through the OFA can be ordered directly via the OFA website (DNA Based Disease Tests – OFA).

Below is a comprehensive list of the tests we offer by breed with links to the disease descriptions and to instructions for submitting samples for testing.  This includes tests offered through the OFA.

DNA Test List by Breed

All Breeds (including mixed breeds)

Degenerative Myelopathy

Disease description: OMIA:000263-9615: Degenerative myelopathy in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals

Gene: SOD1

Methemoglobinemia

Disease description:

Gene:

Alapha Bulldog

Dermatosparaxis Ehlers-Danlos syndrome

Disease description: OMIA:000328-9615: Dermatosparaxis Ehlers-Danlos syndrome (dEDS), ADAMTS2-related in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals

Gene: ADAMTS2

American Bulldog

Neuronal Ceroid Lipofuscinosis (CLN10 Disease)

Disease description: OMIA:001505-9615: Neuronal ceroid lipofuscinosis, 10 in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals

Gene:  CTSD

American Eskimo Dog

Primary Lens Luxation

Disease description:

Gene:

American Staffordshire Terrier

Neuronal Ceroid Lipofuscinosis (Lysosomal Storage Disease)

Disease description: OMIA:001503-9615: Lysosomal storage disease, ARSG related in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals

Gene:  ARSG

Juvenile Laryngeal Paralysis & Polyneuropathy

Disease description:

Gene:  To be published.

Australian Cattle Dog

Neuronal Ceroid Lipofuscinosis (CLN5 Disease)

Disease description: OMIA:001482-9615: Neuronal ceroid lipofuscinosis, 5 in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals

Gene: CLN5

Neuronal Ceroid Lipofuscinosis (CLN8 Disease)

Disease description: OMIA:001506-9615: Neuronal ceroid lipofuscinosis, 8 in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals

Gene: CLN8

Primary Lens Luxation

Disease description:

Gene:

Australian Shepherd

Neuronal Ceroid Lipofuscinosis (CLN6 Disease)

Disease description: OMIA:001443-9615: Neuronal ceroid lipofuscinosis, 6 in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals

Gene: CLN6

Neuronal Ceroid Lipofuscinosis (CLN8 Disease)

Disease description: OMIA:001506-9615: Neuronal ceroid lipofuscinosis, 8 in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals

Gene: CLN8

Basenji

Fanconi Syndrome

Disease description: OMIA:002683-9615: Fanconi syndrome, FAN1-related in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals

Gene: FAN1

Progressive Retinal Atrophy

Disease description: OMIA:001876-9615: Retinal atrophy, progressive, SAG-related in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals

Gene: SAG

Basset Hound

Mucopolysaccharidosis

Disease description: OMIA:000664-9615: Mucopolysaccharidosis I in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals

Gene: IDUA

Bernese Mountain Dogs

Degenerative Myelopathy (SOD1-B)

Disease description:

Gene: SOD1

Black Russian Terrier

Polyneuropathy & Juvenile Laryngeal Paralysis

Disease description: OMIA:001970-9615: Polyneuropathy, RAB3GAP1-related in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals

Gene: RAB3GAP1

Border Collie

Neuronal Ceroid Lipofuscinosis (CLN5 Disease)

Disease description: OMIA:001482-9615: Neuronal ceroid lipofuscinosis, 5 in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals

Gene: CLN5

Primary Lens Luxation (PLL)

Disease description: OMIA:000588-9615: Lens luxation in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals

Gene: ADAMTS17

Glaucoma and Lens Luxation

Disease description:

Gene: LTBP2

Border Terrier

Spongiform-leukoencephalomyelopathy (Shaking Puppy Syndrome)

Disease description:

Gene: OPA1

Cane Corso

Neuronal Ceroid Lipofuscinosis (CLN1 Disease)

Disease description: OMIA:001504-9615: Neuronal ceroid lipofuscinosis, 1 in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals

Gene: PPT1

Dental-skeletal-retinal anomaly

Disease description: OMIA:001504-9615: Neuronal ceroid lipofuscinosis, 1 in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals

Gene: MAI3

Catahoula Leopard Dog

Ehlers-Danlos Syndrome

Disease description:

Gene:

Chihuahua

Neuronal Ceroid Lipofuscinosis (CLN7 Disease)

Disease description: OMIA:001962-9615: Neuronal ceroid lipofuscinosis, 7 in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals

Gene: MFSD8

Primary Lens Luxation

Disease description:

Gene:

Chinese Crested

Neuronal Ceroid Lipofuscinosis (CLN7 Disease)

Disease description: OMIA:001962-9615: Neuronal ceroid lipofuscinosis, 7 in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals

Gene: MFSD8

Multiple System Degeneration

Disease description: OMIA:001468-9615: Multiple system degeneration, SERAC1-related in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals

Gene: SERAC1

Primary Lens Luxation

Disease description:

Gene:

Chinese Foo Dog

Primary Lens Luxation

Disease description:

Gene:

Chinese Shar-Pei

Lens Luxation & Glaucoma

Disease description: OMIA:000588-9615: Lens luxation in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals Gene: ADAMTS17

Clumber Spaniel

Pyruvate dehydrogenase deficiency

Disease description: OMIA:001406-9615: Pyruvate dehydrogenase deficiency in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals

Gene: PDP1

Coton de Tulear

Neonatal Cerebellar Ataxia (Bandera’s syndrome)

Disease description:

Gene:

Dachshund

Neuronal Ceroid Lipofuscinosis (CLN2 Disease)

Disease description: OMIA:001472-9615: Neuronal ceroid lipofuscinosis, 2 in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals

Gene: TPP1

Retinal Atrophy – Cone Rod Dystrophy

Disease description: OMIA:001432-9615: Retinal atrophy – Cone-rod dystrophy 4 in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals

Gene: RPGRIP1

Glycogen Storage Disease

Disease description: OMIA:000421-9615: Glycogen storage disease VII in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals

Gene: PFKM

Dalmatian

Leukodystrophy/Lysosomal Storage Disease

Disease description:  OMIA:002591-9615: Lysosomal storage disease, CNP-related in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals

Gene: CNP

Doberman Pinscher

Dancing Doberman Syndrome

Disease description:

Gene: Unpublished discovery

Ehlers-Danlos Syndrome

Disease description:

Gene:

English Cocker Spaniel

Adult-onset Neuropathy

Disease description:

Gene:

English Springer Spaniel

Progressive Retinal Atrophy (PRA)

Disease description: OMIA:001432-9615: Retinal atrophy – Cone-rod dystrophy 4 in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals

Gene: RPGRIP1

Progressive Retinal Atrophy (PRA)

Disease description: OMIA:001876-9615: Retinal atrophy, progressive, SAG-related in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals

Gene: SAG

Glycogen Storage Disease

Disease description: OMIA:000421-9615: Glycogen storage disease VII in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals

Gene: PFKM

Phosphofructokinase Deficiency

Disease description:

Gene:

English Setter

Neuronal Ceroid Lipofuscinosis (CLN8 Disease)

Disease description: OMIA:001506-9615: Neuronal ceroid lipofuscinosis, 8 in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals

Gene: CLN8

Field Spaniel

Adult-onset Neuropathy

Disease description:

Gene:

German Shepherd

Neuronal Ceroid Lipofuscinosis (CLN8 Disease)

Disease description: OMIA:001506-9615: Neuronal ceroid lipofuscinosis, 8 in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals

Gene: CLN8

Golden Retriever

Neuronal Ceroid Lipofuscinosis (CLN5 Disease)

Disease description: OMIA:001482-9615: Neuronal ceroid lipofuscinosis, 5 in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals

Gene: CLN5

GM1-Gangliosidosis

Disease description:

Gene:

Havanese

Neonatal Cerebellar Ataxia (Bandera’s Syndrome)

Disease description:

Gene:

Jack Russell Terrier

Neonatal Ataxia

Disease description:

Gene: GRID2

Spinocerebellar Ataxia

Disease description: OMIA:001820-9615: Ataxia, spinocerebellar, CAPN1-related in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals

Gene: CAPN1

Spinocerebellar Ataxia

Disease description: OMIA:002089-9615: Ataxia, cerebellar, KCNJ10-related in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals

Gene: KCNJ10