Canine Genetics Laboratory Testing
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DNA Tests Performed by the University of Missouri Canine Genetics Laboratory
The University of Missouri Canine Genetics Laboratory performs testing to identify selected disease-causing mutations in dogs. Some of our testing is offered in coordination with the Orthopedic Foundation for Animals (OFA). The tests offered through the OFA can be ordered directly via the OFA website (DNA Based Disease Tests – OFA).
Below is a comprehensive list of the tests we offer by breed with links to the disease descriptions and to instructions for submitting samples for testing. This includes tests offered through the OFA.
DNA Test List by Breed
All Breeds (including mixed breeds)
Degenerative Myelopathy
Disease description: OMIA:000263-9615: Degenerative myelopathy in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals
Gene: SOD1
Methemoglobinemia
Disease description:
Gene:
Alapha Bulldog
Dermatosparaxis Ehlers-Danlos syndrome
Disease description: OMIA:000328-9615: Dermatosparaxis Ehlers-Danlos syndrome (dEDS), ADAMTS2-related in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals
Gene: ADAMTS2
American Bulldog
Neuronal Ceroid Lipofuscinosis (CLN10 Disease)
Disease description: OMIA:001505-9615: Neuronal ceroid lipofuscinosis, 10 in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals
Gene: CTSD
American Eskimo Dog
Primary Lens Luxation
Disease description:
Gene:
American Staffordshire Terrier
Neuronal Ceroid Lipofuscinosis (Lysosomal Storage Disease)
Disease description: OMIA:001503-9615: Lysosomal storage disease, ARSG related in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals
Gene: ARSG
Juvenile Laryngeal Paralysis & Polyneuropathy
Disease description:
Gene: To be published.
Australian Cattle Dog
Neuronal Ceroid Lipofuscinosis (CLN5 Disease)
Disease description: OMIA:001482-9615: Neuronal ceroid lipofuscinosis, 5 in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals
Gene: CLN5
Neuronal Ceroid Lipofuscinosis (CLN8 Disease)
Disease description: OMIA:001506-9615: Neuronal ceroid lipofuscinosis, 8 in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals
Gene: CLN8
Primary Lens Luxation
Disease description:
Gene:
Australian Shepherd
Neuronal Ceroid Lipofuscinosis (CLN6 Disease)
Disease description: OMIA:001443-9615: Neuronal ceroid lipofuscinosis, 6 in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals
Gene: CLN6
Neuronal Ceroid Lipofuscinosis (CLN8 Disease)
Disease description: OMIA:001506-9615: Neuronal ceroid lipofuscinosis, 8 in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals
Gene: CLN8
Basenji
Fanconi Syndrome
Disease description: OMIA:002683-9615: Fanconi syndrome, FAN1-related in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals
Gene: FAN1
Progressive Retinal Atrophy
Disease description: OMIA:001876-9615: Retinal atrophy, progressive, SAG-related in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals
Gene: SAG
Basset Hound
Mucopolysaccharidosis
Disease description: OMIA:000664-9615: Mucopolysaccharidosis I in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals
Gene: IDUA
Bernese Mountain Dogs
Degenerative Myelopathy (SOD1-B)
Disease description:
Gene: SOD1
Black Russian Terrier
Polyneuropathy & Juvenile Laryngeal Paralysis
Disease description: OMIA:001970-9615: Polyneuropathy, RAB3GAP1-related in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals
Gene: RAB3GAP1
Border Collie
Neuronal Ceroid Lipofuscinosis (CLN5 Disease)
Disease description: OMIA:001482-9615: Neuronal ceroid lipofuscinosis, 5 in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals
Gene: CLN5
Primary Lens Luxation (PLL)
Disease description: OMIA:000588-9615: Lens luxation in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals
Gene: ADAMTS17
Glaucoma and Lens Luxation
Disease description:
Gene: LTBP2
Border Terrier
Spongiform-leukoencephalomyelopathy (Shaking Puppy Syndrome)
Disease description:
Gene: OPA1
Cane Corso
Neuronal Ceroid Lipofuscinosis (CLN1 Disease)
Disease description: OMIA:001504-9615: Neuronal ceroid lipofuscinosis, 1 in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals
Gene: PPT1
Dental-skeletal-retinal anomaly
Disease description: OMIA:001504-9615: Neuronal ceroid lipofuscinosis, 1 in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals
Gene: MAI3
Catahoula Leopard Dog
Ehlers-Danlos Syndrome
Disease description:
Gene:
Chihuahua
Neuronal Ceroid Lipofuscinosis (CLN7 Disease)
Disease description: OMIA:001962-9615: Neuronal ceroid lipofuscinosis, 7 in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals
Gene: MFSD8
Primary Lens Luxation
Disease description:
Gene:
Chinese Crested
Neuronal Ceroid Lipofuscinosis (CLN7 Disease)
Disease description: OMIA:001962-9615: Neuronal ceroid lipofuscinosis, 7 in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals
Gene: MFSD8
Multiple System Degeneration
Disease description: OMIA:001468-9615: Multiple system degeneration, SERAC1-related in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals
Gene: SERAC1
Primary Lens Luxation
Disease description:
Gene:
Chinese Foo Dog
Primary Lens Luxation
Disease description:
Gene:
Chinese Shar-Pei
Lens Luxation & Glaucoma
Disease description: OMIA:000588-9615: Lens luxation in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals Gene: ADAMTS17
Clumber Spaniel
Pyruvate dehydrogenase deficiency
Disease description: OMIA:001406-9615: Pyruvate dehydrogenase deficiency in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals
Gene: PDP1
Coton de Tulear
Neonatal Cerebellar Ataxia (Bandera’s syndrome)
Disease description:
Gene:
Dachshund
Neuronal Ceroid Lipofuscinosis (CLN2 Disease)
Disease description: OMIA:001472-9615: Neuronal ceroid lipofuscinosis, 2 in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals
Gene: TPP1
Retinal Atrophy – Cone Rod Dystrophy
Disease description: OMIA:001432-9615: Retinal atrophy – Cone-rod dystrophy 4 in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals
Gene: RPGRIP1
Glycogen Storage Disease
Disease description: OMIA:000421-9615: Glycogen storage disease VII in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals
Gene: PFKM
Dalmatian
Leukodystrophy/Lysosomal Storage Disease
Disease description: OMIA:002591-9615: Lysosomal storage disease, CNP-related in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals
Gene: CNP
Doberman Pinscher
Dancing Doberman Syndrome
Disease description:
Gene: Unpublished discovery
Ehlers-Danlos Syndrome
Disease description:
Gene:
English Cocker Spaniel
Adult-onset Neuropathy
Disease description:
Gene:
English Springer Spaniel
Progressive Retinal Atrophy (PRA)
Disease description: OMIA:001432-9615: Retinal atrophy – Cone-rod dystrophy 4 in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals
Gene: RPGRIP1
Progressive Retinal Atrophy (PRA)
Disease description: OMIA:001876-9615: Retinal atrophy, progressive, SAG-related in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals
Gene: SAG
Glycogen Storage Disease
Disease description: OMIA:000421-9615: Glycogen storage disease VII in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals
Gene: PFKM
Phosphofructokinase Deficiency
Disease description:
Gene:
English Setter
Neuronal Ceroid Lipofuscinosis (CLN8 Disease)
Disease description: OMIA:001506-9615: Neuronal ceroid lipofuscinosis, 8 in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals
Gene: CLN8
Field Spaniel
Adult-onset Neuropathy
Disease description:
Gene:
German Shepherd
Neuronal Ceroid Lipofuscinosis (CLN8 Disease)
Disease description: OMIA:001506-9615: Neuronal ceroid lipofuscinosis, 8 in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals
Gene: CLN8
Golden Retriever
Neuronal Ceroid Lipofuscinosis (CLN5 Disease)
Disease description: OMIA:001482-9615: Neuronal ceroid lipofuscinosis, 5 in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals
Gene: CLN5
GM1-Gangliosidosis
Disease description:
Gene:
Havanese
Neonatal Cerebellar Ataxia (Bandera’s Syndrome)
Disease description:
Gene:
Jack Russell Terrier
Neonatal Ataxia
Disease description:
Gene: GRID2
Spinocerebellar Ataxia
Disease description: OMIA:001820-9615: Ataxia, spinocerebellar, CAPN1-related in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals
Gene: CAPN1
Spinocerebellar Ataxia
Disease description: OMIA:002089-9615: Ataxia, cerebellar, KCNJ10-related in Canis lupus familiaris (dog) – OMIA – Online Mendelian Inheritance in Animals
Gene: KCNJ10