Etiology: Mouse thymic virus (MTV) is an enveloped DNA virus of the family Herpesviridae.
Incidence: The incidence of infection is rare.
Transmission: Transmission occurs by direct contact with saliva.
Clinical Signs: Spontaneous infections with MTV are asymptomatic. Experimental infection in neonates less than 10 days of age causes immunosuppression.
Pathology: In mice inoculated before 10 days of age, characteristic lesions include intranuclear inclusions in thymocytes and thymic necrosis.
Diagnosis: Diagnosis of MTV can be made using IFA or PCR. Observation of thymic necrosis on histology may confirm diagnosis.