Etiology: There are several factors thought to predispose rats to this condition including chronic myocarditis or myocardial ischemia. Age and the concomitant development of chronic progressive nephropathy may also contribute.
Incidence: Incidence is common, especially in SD rats. Older males are more commonly affected.
Clinical Signs: Usually there are no clinical signs.
Pathology: Grossly, there may be multifocal grey lesions in the left ventricle. Histologically, there is myocardial atrophy, necrosis and collagen deposition (fibrosis) with interstitial infiltration with mononuclear cells .
Diagnosis: Diagnosis is made based on histopathologic findings.
3. The Laboratory Rat, ed. M.A. Suckow, Weisbroth, Steven H., Franklin, Craig L.2006, 30 Corporate Drive, Suite 400, Burlington, MA 01803 Elsevier.