Srinand Sreevatsan, BVSC, MVSC, MPH, PhD

Professor

Dean of the College of Veterinary Medicine

  • BVSc
  • MVSc
  • MPH
  • PhD
RESEARCH INTERESTS

The goal of Dr. Sreevatsan’s research is to advance an understanding of pathogen-host interactions through a systems approach. By using advanced technologies like genome sequencing and functional genomics, the interdisciplinary research strategy aims to uncover new insights into zoonotic pathogen infections. Studying the interactions and interplay of many levels of biological information systems enables researchers to understand and cure complex infectious diseases. This work is collaborative and involves partnerships with local, national, and international investigators with diverse areas of expertise in bacterial and viral diseases. Dr. Sreevatsan’s scientific inquiry focuses on the worlds’ greatest infectious diseases such as those caused by mycobacteria, prions, and influenza A. This work provides a scientific basis for improved disease surveillance and mitigation through development of improved diagnostic tests and methods for microbial identification/tracking, as well as developing new generations of antimicrobial vaccines and therapeutics.

Guiding Principles (Sreevatsan Lab)

Dr. Sreevatsan’s work on mycobacteria began in 1995 with investigations on the molecular basis of drug resistance in the M. tuberculosis complex. Building on that experience, he added newer technologies to improve the resolution of understanding pathogenesis in the natural host. His work has contributed significantly to the understanding of genomic diversity in mycobacteria, mycobacterium-host interactions in natural infections, serum biomarkers of mycobacterial infections and their response to treatment, iron physiology in mycobacteria, and microbial population structure and functioning in pathogen-induced environments. These findings have been funded by USDA and published in high impact and widely read journals including, Proceedings of the National Academy of Sciences, Nature Medicine, Analyst, BMC Microbiology, BMC Genomics, Journal of Clinical Microbiology, PLoS One, Microbes and Infection, Frontiers in Cellular Microbiology, Infection and Immunity, and Antimicrobial agents and chemotherapy.

Studies on influenza virus ecology and evolution involve the investigation of viral population structures in avian and swine populations and their contribution to the emergence of novel subtypes. This work feeds into the evaluation of host specific immune responses, extensive viral diversity and development of universal vaccines. His work on influenza viruses received funding by the USDA and NIH. Findings have been published in PLoS One, EMI, Virology, and the Journal of Clinical Microbiology.

SELECTED PUBLICATIONS

Singhla T, Boonyayatra S, Sthitmatee N, Sirimalaisuwan A, Maicharoen N, Meemey A, Muenthaisong A, Rittipornlertrak A, Sreevatsan S. (2024) An ELISA test using a circulating Mycobacterium bovis peptide for detecting bovine tuberculosis in dairy cattle. Front Vet Sci. 2024 May 22;11:1384537. doi: 10.3389/fvets.2024.1384537. PMID: 38840633.

Thapa S, Rathnaiah G, Zinniel DK, Barletta RG, Bannantine JP, Huebner M, Sreevatsan S. (2024) The Fur-like regulatory protein MAP3773c modulates key metabolic pathways in Mycobacterium avium subsp. paratuberculosis under in-vitro iron starvation. Sci Rep. 2024 Apr 18;14(1):8941. doi: 10.1038/s41598-024-59691-3. PMID: 38637716.

Goncalves JL, Mani R, Sreevatsan S, Ruegg PL. (2023) Apparent prevalence and selected risk factors of methicillin-resistant Staphylococcus aureus and non- aureus staphylococci and mammaliicocci in bulk tank milk of dairy herds in Indiana, Ohio, and Michigan. JDS Commun. 2023 Oct 3;4(6):489-495. doi: 10.3168/jdsc.2023-0386. eCollection 2023 Nov. PMID: 38045889.

Brenner EP, Sreevatsan S. (2023) Global-scale GWAS associates a subset of SNPs with animal-adapted variants in M. tuberculosis complex. BMC Med Genomics. 2023 Oct 24;16(1):260. doi: 10.1186/s12920-023-01695-5. PMID: 37875894.

Brenner EP, Sreevatsan S. (2023) Attenuated but immunostimulatory Mycobacterium tuberculosis variant bovis strain Ravenel shows variation in T cell epitopes. Sci Rep. 2023 Jul 31;13(1):12402. doi: 10.1038/s41598-023-39578-5. PMID: 37524777.

Brenner E, Sreevatsan S. (2023) Cold Cas: reevaluating the occurrence of CRISPR/Cas systems in Mycobacteriaceae. Front Microbiol. 2023 Jun 27;14:1204838. doi: 10.3389/fmicb.2023.1204838. eCollection 2023. PMID: 37440893.

Hadi SA, Brenner EP, Palmer MV, Waters WR, Thacker TC, Vilchèze C, Larsen MH, Jacobs WR Jr, Sreevatsan S. (2022) Mycobacterium bovis Strain Ravenel Is Attenuated in Cattle. Pathogens. 2022 Nov 11;11(11):1330. doi: 10.3390/pathogens11111330. PMID: 36422582.

Gass JD Jr, Dusek RJ, Hall JS, Hallgrimsson GT, Halldórsson HP, Vignisson SR, Ragnarsdottir SB, Jónsson JE, Krauss S, Wong SS, Wan XF, Akter S, Sreevatsan S, Trovão NS, Nutter FB, Runstadler JA, Hill NJ. (2022) Global dissemination of influenza A virus is driven by wild bird migration through arctic and subarctic zones. Mol Ecol. 2023 Jan;32(1):198-213. doi: 10.1111/mec.16738. Epub 2022 Oct 26. PMID: 36239465.

Holz CL, Darish JR, Straka K, Grosjean N, Bolin S, Kiupel M, Sreevatsan S. (2022) Evaluation of Real-Time Quaking-Induced Conversion, ELISA, and Immunohistochemistry for Chronic Wasting Disease Diagnosis. Front Vet Sci. 2022 Jan 18;8:824815. doi: 10.3389/fvets.2021.824815. eCollection 2021. PMID: 35118153.

Brenner EP, Hadi SA, Harris B, Robbe-Austerman S, Sreevatsan S. (2021) Genome Sequences of Mycobacterium Strains Recovered from Captive Elephants with Tuberculosis. Microbiol Resour Announc. 2021 Sep 9;10(36):e0067121. doi: 10.1128/MRA.00671-21. Epub 2021 Sep 9. PMID: 34498929.